School of Medicine - Basic Medical ScienceBiochemistry II




The Department of Biochemistry II takes charge of the lectures and laboratories on biochemistry and molecular biology for the first- and second-year medical students.
Our major research projects are:
1. Molecular mechanisms of the regulation of vascular network formation.
2. Roles and molecular basis of neuro-vascular interactions.
3. Mechanisms of regulation of alternative pre-mRNA processing.
4. Molecular mechanisms of development of eye diseases.
Please see the references listed below.

Contact Information

TEL: 076-218-8111 +81-76-218-8111 / FAX: 076-218-8111 +81-76-218-8111 / Email:


Professor and Chair

  • YONEKURA Hideto 2生化米倉

Senior Assistant Professor

  • IKEDA Takayuki

Assistant Professor

  • AKATSUJI - SAITO Hidehito

Adjunct Lecturer

  • YOSHITAKE Yoshino

Research Achievements

Research Activities

  • Ikeda T, Yoshitomi Y, Saito H, Shimasaki T, Yamaya H, Kobata T, Ishigaki Y, Tomosugi N, Yoshitake Y, Yonekura H. Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation. Mol. Cell. Biochem. 413(1-2): 155-164 (2016)
  • Ikeda T, Takasawa S, Noguchi N, Nata K, Yamauchi A, Takahashi I, Yoshikawa T, Sugawara A, Yonekura H, Okamoto H. Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian cells and evolutional conservation of the enzyme from human to invertebrate. Mol. Cell. Biochem. 366(1-2):69-80 (2012)
  • Sugihara T, Munesue S, Yamamoto Y, Sakurai S, Akhter N, Kitamura Y, Shiba K, Watanabe T, Yonekura H, Hayashi Y, Hamada J, Yamamoto H. Endogenous Secretory Receptor for Advanced Glycation End-products Inhibits Amyloid-beta1-42 Uptake into Mouse Brain. J. Alzheimers Dis. 28(3):709-720 (2012)
  • Ikeda T, Sun L, Tsuruoka N, Ishigaki Y, Yoshitomi Y, Yoshitake Y, Yonekura H. Hypoxia down-regulates sFlt-1 (sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing. Biochem. J. 436 (2), 399-407 (2011)
  • Osada H, Yoshitake Y, Ikeda T, Ishigaki Y, Takata T, Tomosugi N, Sasaki H, Yonekura H. Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells. Mol. Vis. 17:159-169 (2011)

External Research Funding

  • JSPS KAKENHI Grant Number 24790297 (Grant-in-Aid for Young Scientists (B),Yasuo Yoshitomi, 2012~2015, Novel functions of JunB in the vascular network development via neuro-vascular interactions.)
  • JSPS KAKENHI Grant Number 23590349 (Grant-in-Aid for Scientific Research (C), Hideto Yonekura, 2011~2013, Molecular basis of induction of sinusoid-like tumor vessels by high metastatic Lewis lung carcinoma cells.)
  • JSPS KAKENHI Grant Number 00374942 (Grant-in-Aid for Young Scientists (B),Takayuki Ikeda, 2011~2013, In vivo analysis of roles of the soluble VEGF receptor (sFlt-1) in retinal vasculogenesis.)
  • JSPS KAKENHI Grant Number 20590290 (Grant-in-Aid for Scientific Research (C), Hideto Yonekura, 2008~2010, Identification of genes involved in the vascular network formation though neuro-vascular interactions.)
  • JSPS KAKENHI Grant Number 20592063 (Grant-in-Aid for Scientific Research (C), Yoshino Yoshitake,2008~2010, Inhibition of angiogenesis through a targeting miRNA.)